The discovery of the antibacterial effect of molds from which penicillin was made was a real revolution in medicine. But over time, the pathogenic microflora adapted to the action of this drug. This forced scientists to develop synthetic ones, one of which was Flemoxin Solutab. The instructions and description of the drug will help to avoid its negative effects on the body and side effects.
Active ingredient of the drug
One tablet of "Flemoxin" contains acid-resistant amoxicillin in the form of 125, 250, 500 and 1000 milligrams. This substance has a strong bactericidal effect. Drugs with amoxicillin are also used against gram-positive and gram-negative bacteria. Sometimes used to combat pathogens of intestinal infections. But in the latter case it is less effective.
Dosage form, composition
What is Flemoxin Solutab (500 mg)? Instructions for use describe the drug in various dosages (125 and 250, 1000 and 500 mg) as oval tablets with a light yellow color. Each tablet has a company logo and a digital designation on one side, and a risk on the other side.In the manufacture of the drug, such excipients as monocrystalline cellulose, vanillin, dispersible cellulose, magnesium stearate, crospovidone, saccharin, and flavorings were used.
The drug is intended for systemic use and is a broad-spectrum drug.
Pharmacological effect on the body
How does it affect the body? The instructions say that after taking the active ingredient of the drug - amoxicillin - almost everything is absorbed in the shortest possible time (almost 93 percent). Moreover, the absorption of the drug is in no way related to food intake.
In the blood plasma, the maximum amount of the drug is detected one to two hours after administration. After the drug “Flemoxin Solutab 500 mg” enters the digestive tract (the instructions for use confirm this), the maximum concentration of amoxicillin is observed by researchers after 2 hours. This maximum is 5 mcg/ml. If for some reason the dose of a medicine is reduced or increased, then its concentration, accordingly, decreases or increases.
Twenty percent of the substance binds to plasma proteins. The therapeutic effect is almost always achieved, since the drug penetrates perfectly into the intraocular fluid, bones, mucous membranes, and sputum. Two or even four times more amoxicillin enters the bile than plasma. Twenty-five to thirty percent of flemoxin is found in the umbilical cord and amniotic substance of its concentration in the blood of a pregnant woman.
Poor penetration of the active substance through the blood-brain barrier was noted: its amount in the cerebrospinal fluid when consumed does not exceed twenty percent.
The drug is excreted by the kidneys. Eighty percent of the active substance is processed by tubular excretion, the remaining twenty are filtered by the glomeruli. Healthy kidneys take about an hour and a half to eliminate amoxicillin. In children under six months of age, the half-life is three to four hours. Liver dysfunction does not affect the half-life of the drug.
Pharmacodynamics
"Flemoxin Solutab" (500 mg tablet, 20 pcs., like other dosages of the drug) is an acid-resistant bactericidal antibacterial agent with a wide spectrum of action. They assign him to the group
It has a detrimental effect on many gram-negative and gram-positive microorganisms, such as most varieties of streptococci, clostridia, staphylococci, Helicobacter, Escherichia coli, Protea, salmonella,
In what cases is the drug prescribed?
In what cases is Flemoxin Solutab (500 mg) prescribed? The instructions for use confirm (this also applies to other dosages of the drug) that the drug is effective:
- with infectious processes in the respiratory tract;
- for infectious diseases of the genitourinary organs;
- for the treatment of gastrointestinal infections;
- for skin infections and infectious processes in soft tissues.
Who is contraindicated from using the drug?
"Flemoxin Solutab" (table 500 mg n20), the instructions confirm this, has not only advantages, it also has its contraindications. This is also true for other dosages of the drug. The drug is not prescribed or prescribed with great caution in the following cases:
- if the patient had an allergic reaction to it or other antibiotics of this series;
- patients with lymphocytic leukemia or infectious mononucleosis;
- children under six years of age are prescribed with caution in the form of a suspension;
- with renal failure;
- for diseases of the gastrointestinal tract, especially those arising from the use of antibiotics;
- Pregnant women or during breastfeeding are prescribed if the need for the drug outweighs the possible risks.
Use of medication in adults
Adults and children over ten years old and forty kilograms in weight are most often prescribed Flemoxin Solutab 500 mg. Instructions for use indicate the need to take the drug three times a day. If it is severe and with complications, a dosage of 0.75 to 1 gram 3 times a day is allowed. Gonorrhea without complications in adults requires the administration of three grams of the drug at a time. Women are prescribed the same dose again.
Infectious diseases of the stomach, intestines and biliary tract, as well as gynecological diseases of an infectious nature are treated with three daily doses in a dosage of one and a half to two grams or four daily doses - one to one and a half grams at a time.
Adults with leptospirosis are treated with four doses of Flemoxin Solutab, 0.5-0.7 grams. Treatment should last from six to twelve days.
Carriage of salmonella requires three applications of one and a half to two grams for two to four weeks.
To avoid endocarditis during minor surgical interventions, three to four grams of the drug are prescribed an hour before surgery. If there is a need to re-use the drug, it is prescribed eight to nine hours later in the same dosage.
If kidney function is impaired, the interval between doses should be up to 12 hours. For more serious disorders, reduce the dose. If the patient has anuria, the maximum dose should not exceed two grams.
"Flemoxin Solutab" for children - dosage
In most cases, this drug is used in the form of a suspension for children. How is Flemoxin Solutab used for children? Dosage and purpose depend on the age, weight of the patient, and the severity of the infectious process. If a child is from five to ten years old, the drug is prescribed at a dose of 250 mg, from two to five years old - 125 mg, up to two years old - 200 mg. For severe disease, use 60 mg/kg three times a day. The course of treatment with this medication is from six to twelve days.
For newborns and premature babies, the dose is reduced or the interval between doses is increased. To prevent endocarditis during minor surgical operations, one and a half to two grams are prescribed an hour before the procedure. If necessary, re-prescribe eight to nine hours after surgery.
What side effects may be associated with the use of the drug?
Whatever the ideal medicine, no matter what natural ingredients it is created from, there are risks of side effects that can affect the patient’s condition.
- Allergic reactions can result from any dosage of the drug, including "Flemoxin Solutab" 500 mg 20, the price and instructions of which are almost the same in all dosage forms used. Redness of the skin, rashes in the form of erythema, and angioedema may also be observed.
- Occasionally, serum sickness and anaphylactic shock, fever, eosinophilia, and arthralgia are observed.
- On the part of the digestive system, nausea, dysbacteriosis, diarrhea, vomiting, changes in taste sensations, and pseudomembranous enterocolitis are possible. ALT and AST may increase.
- Changes in the nervous system: sleep disturbances, anxiety, depressive symptoms, pain and dizziness, episyndrome, disturbances of consciousness, ataxia may be observed.
- Laboratory parameters change: the number of leukocytes and erythrocytes decreases, hemoglobin decreases, and neutropenia is noted.
- Possible respiratory failure, increased heart rate, nephritis, vaginal candidiasis, and even greater development of infection (in patients with chronic processes and reduced immunity).
- An overdose of the drug manifests itself in the form of diarrhea, vomiting and nausea, which may result in disturbances in water and electrolyte balance. Gastric lavage, saline laxatives, activated charcoal, and sometimes hemodialysis are prescribed.
"Flemoxin Solutab": reviews, analogues, application
Patients rate this drug as very effective and relatively safe. It is bioavailable, so its effect appears very quickly. After starting treatment, the condition of adults and children improves within the first 24 hours. Depending on the dosage and purpose, Flemoxin Solutab is very quickly absorbed into the blood. Its action lasts for eight hours. In this case, the concentration of the substance is noted 15 minutes after use.
As experts note, this antibiotic is one of the safest for children. It is used from early childhood as prescribed by a doctor.
This drug has many synonyms, that is, drugs that are made on the basis of amoxicillin. But there are also some medicines with a different active ingredient, but used for the same health problems as Flemoxin Solutab. Such drugs are called analogues of the above. The active ingredients in them are also antibiotics, semi-synthetic penicillins. They are used for sepsis, abscesses, infections of the ENT organs and respiratory tract, genitourinary tract, skin, gastrointestinal tract, soft tissues and so on.
These drug analogues include:
- "Azlocillin" - the active substance is azlocillin.
- "Ampik" - acts with the help of ampicillin.
- "Geopen" - the main substance is carbenicillin.
- "Isipen" - the active substance is piperacillin.
- "Penglob" - affects the body with the help of bacampicillin.
- "Flucloxacillin" - the active substance has the same name.
Analogs of the drug, especially antibiotics, should be discussed with your doctor. This is very important, since the dosage, nature of treatment and duration are determined only by a specialist. He also knows better which active ingredient is suitable in a particular case.
Features of the drug, price
Most patients are interested in the indications for the drug "Flemoxin Solutab", instructions for use, price, description, features of use.
If drug treatment is carried out in courses, the function of the kidneys, liver, and hematopoiesis should be monitored.
If the patient is sensitive to the penicillin group, cross-allergic manifestations may occur.
If mild diarrhea occurs during treatment, drugs that reduce intestinal motility should be avoided. If severe diarrhea occurs, you should seek advice from a medical facility. After the disappearance of clinical manifestations, it is recommended to take Flemoxin Solutab for another three to four days.
The drug may reduce the contraceptive effect of oral contraceptives, so additional contraception should be taken while taking it. It also does not combine well with aminoglycosides, indirect anticoagulants, methotrexate, digoxin, alopurinol, diuretics, and oxyphenbutazone.
Before use, it is important to familiarize yourself with the features of using the drug "Flemoxin Solutab". Instructions for use and reviews will help you avoid unwanted consequences.
Prices for the drug in different cities range from 176 rubles (in Nizhny Novgorod) to 228 rubles (in Novosibirsk). In the capital, "Flemoxin Solutab" can be purchased at a price of 191 rubles. In St. Petersburg it costs an average of 184 rubles.
Do not forget that the instructions for use of the drug "Flemoxin Solutab" are mainly compiled for the doctor. And only he can prescribe or cancel the medicine. Avoid self-medication!
